AH-EXT-195

Title

Impact of Caloric Restriction on Metabolomic Aging

Summary of Proposal

Aging research suggests that targeting individual disease processes will generate only modest improvements in health outcomes. Instead, it has been proposed that the most effective means to improve health is to target aging processes directly. One of the most promising interventions is caloric restriction.

The overarching goal of this proposal is to describe the distribution of metabolomic aging in a robust reference population via metabolomic age scores, and then explore the impact of caloric restriction on changes in metabolomic aging. In particular, this project will accomplish the following: 

1. Construct and implement metabolomic aging scores in COMETS cohorts to describe the distribution of metabolomic aging scores across sociodemographic strata
2. Implement metabolomic aging scores in CALERIE to test if caloric restriction reduces the rate of metabolomic aging
3. Investigate functional significance of metabolites in metabolomic age scores