The Airwave Tissue Bank is an epidemiological study of police officers and staff in Britain. It is managed and run by the Department of Epidemiology & Biostatistics at Imperial College London, and we believe it to be the only large-scale cohort study of police employees anywhere in the world.

The cohort has been richly phenotyped, flagged to routine records, and has a substantial biobank of blood and urine samples. It provides an excellent and unique resource to study the genetic, metabolic, occupational and lifestyle factors associated with mental health and cognitive performance among a predominantly male and young adult workforce with a well-defined organisational hierarchy.

The cohort was established in 2004 to investigate possible long-term health effects associated with use of TETRA, the radio system used by the police service. Mean age at recruitment was 39.8 y (σ = 16.0) and ranged from 16 - 80 y. The mean duration of follow-up at December 2022 is 13.1 y (σ = 2.9). It includes a group – younger men aged between twenty and forty years – who are particularly under-represented in the UK research portfolio, who have proven hard to engage in primary prevention, and have least routine contact with primary care. Some further statistics on the cohort are set out in the table below.

Recruitment was completed in 2015, and over the next four years a series of papers were published to evaluate the effect of TETRA on health. Whilst our overall assessment was that insufficient time has passed to form any final conclusions, we continue to follow-up the cohort through national registers, via follow-up screening and self-administered surveys.

We have also successfully re-purposed the cohort to support broader research goals into common diseases affecting this well-defined occupational group. For example, the cohort made a significant contribution to COVID-19 research, by providing 5985 volunteers for studies into novel methods for diagnosis of SAR-CoV-2 infection. We are core members of Dementia Platform UK (DPUK), UK Longitudinal Linkage Collaboration, and are listed on eight other directories supporting researchers worldwide.

Researchers can apply to our Access Committee for access to samples and data in order to carry out their own research projects. As members of the DPUK public-private partnership, researchers can build a virtual cohort of participants from the many cohorts registered with DPUK. Participants can be selected from their genotype and / or phenotype, and participants may be invited to join researchers' own projects or clinical trials.

Biological Samples

When participants attend clinics, we generally collect a sample of blood and urine in a variety of collection tubes. Following biochemistry and haematology assays, which are carried out generally within 24-hours, we store the remaining material in cryogenic conditions for more detailed assays at a later date. These have included genetic and metabolomic assays, with proteomics planned.

The following is a summary of the biological material available according to our inventories.

Descriptive Statistics by Gender

In the tables below, participants with no information on gender (N=17) are excluded. Means (SD) are presented for age and percentages are presented for all other variables; n refers to the number of participants for whom each variable is available.

Means (SD) and percentages are presented for continuous and categorical variables respectively; n refers to the number of participants for whom each variable is available. The following definitions apply:

• SBP: systolic blood pressure.
• DBP: diastolic blood pressure.
• HbA1c: glycosylated haemoglobin.
• GCSE: General Certificate of Secondary Education (usually taken at 16-years)
• Hypertension is defined as systolic blood pressure > 140 mmHg or diastolic blood pressure > 90 mmHg.

Demographics

Age-Sex Distribution at Baseline

Mean age at recruitment was 39.8 (s.d. 9.1; range 16 to 80) years; mean duration of follow-up to date is 13.8 (s.d. 2.9) years.

Ethnicity and Location

For those with ethnicity data, 94.8% self-report as white, 1.3% South Asian, 1.1% Black, 1.1% mixed ethnicity, 1.7% other, reflecting the demography of the police force at that time. 70% of the cohort were recruited in England, 15% in Scotland and 15% in Wales.

Clinical and Biological Measurements by Gender

Education, Marital Status, Rank & Smoking

The graph below is for men and women across categories by education, marital status, rank and smoking among participants who attended a clinic visit at baseline.