Cardio-Metabolomic
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- Huffman JE, et al. Whole genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles. . (2023) https://pubmed.ncbi.nlm.nih.gov/37398003/
- Hahn, J., et al. DNA methylation analysis is used to identify novel genetic loci associated with circulating fibrinogen levels in blood. J Thromb Haemost. 2023 May;21(5):1135-1147. (2023) https://pubmed.ncbi.nlm.nih.gov/36716967/
- Kojouri, M., et al. Metabolome-wide association study on physical activity. Sci Rep 13, 2374. (2023) https://pubmed.ncbi.nlm.nih.gov/36759570/
- Winkler, T.W., Rasheed, H., Teumer, A., et al. Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. Commun Biol 5, 580 (2022). (2022) https://pubmed.ncbi.nlm.nih.gov/35697829/
- Said, S., Pazoki, R., Karhunen, V., et al. Genetic analysis of over half a million people characterises C-reactive protein loci. Nat Commun 13, 2198 (2022).. (2022) https://pubmed.ncbi.nlm.nih.gov/35459240/
- Wielscher, M., et al. DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases. Nature Comms, 13(1), 2408. (2022) https://pubmed.ncbi.nlm.nih.gov/35504910/
- van Vliet, N. A., et al. Higher thyrotropin leads to unfavorable lipid profile and somewhat higher cardiovascular disease risk: evidence from multi-cohort Mendelian randomization and metabolomic profiling. BMC Medicine, 19(1), 266. (2021) https://pubmed.ncbi.nlm.nih.gov/34727949/
- Vasiliki Lagou, et al. Random glucose GWAS in 476,326 individuals provides insights into diabetes pathophysiology, complications and treatment stratification. . (2021) https://pubmed.ncbi.nlm.nih.gov/37679419/
- Surendran, P., Feofanova, E.V., Lahrouchi, N., et al. Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nat Genet 52, 1314–1332 (2020). (2020) https://pubmed.ncbi.nlm.nih.gov/33230300/
- de Las Fuentes, L., et al. Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci. Mol Psychiatry. 2021 Jun;26(6):2111-2125. (2020) https://pubmed.ncbi.nlm.nih.gov/32372009/
- Justice AE, et al. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Nat Genet. 2019 Mar;51(3):452-469. (2019) https://pubmed.ncbi.nlm.nih.gov/30778226/
- Kraja, A. T., et al. Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits. Am J Hum Genet 104, 112-138. (2019) https://www.ncbi.nlm.nih.gov/pubmed/30595373/
- Erzurumluoglu AM, et al. Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. Mol Psychiatry 25, 2392–2409 (2020). (2019) https://pubmed.ncbi.nlm.nih.gov/30617275/
- Kilpeläinen TO, et al. Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nat Commun. Jan 22;10(1):376. (2019) https://pubmed.ncbi.nlm.nih.gov/30670697/
- Bentley, A. R., et al. Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nat Genet 51, 636-648. (2019) https://www.ncbi.nlm.nih.gov/pubmed/30926973/
- Sung, Y. J., et al. A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Hum Mol Genet. 2019 Aug 1;28(15):2615-2633. (2019) https://pubmed.ncbi.nlm.nih.gov/31127295/
- Pazoki R, et al. GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits. Nat Commun. 2019 Aug 13;10(1):3653. (2019) https://pubmed.ncbi.nlm.nih.gov/31409800/
- Turcot, V., et al. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet 50, 26-41. (2018) https://www.ncbi.nlm.nih.gov/pubmed/29273807/
- Sung, Y. J., et al. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Am J Hum Genet. 2018 Mar 1;102(3):375-400. (2018) https://pubmed.ncbi.nlm.nih.gov/29455858/
- Evangelou, E., et al. Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet. 2018 Oct;50(10):1412-1425. (2018) https://pubmed.ncbi.nlm.nih.gov/30224653/
- Warren, H. R., et al. Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet 49, 403-415. (2017) https://www.ncbi.nlm.nih.gov/pubmed/28135244/
- Wain, L. V., et al. Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension. 2017 Sep;70(3):e4-e19. (2017) https://pubmed.ncbi.nlm.nih.gov/28739976/
- van Leeuwen, E. M., et al. Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. J Med Genet 53, 441-449. (2016) https://www.ncbi.nlm.nih.gov/pubmed/27036123/
- Surendran, P., et al. Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nat Genet 48, 1151-1161. (2016) https://www.ncbi.nlm.nih.gov/pubmed/27618447/
- Schumann, G., et al. KLB is associated with alcohol drinking, and its gene product beta-Klotho is necessary for FGF21 regulation of alcohol preference. Proc Natl Acad Sci U S A 113, 14372-14377. (2016) https://www.ncbi.nlm.nih.gov/pubmed/27911795/
- Epstein, S., et al. Numerical assessment of the stiffness index. Conf Proc IEEE Eng Med Biol Soc 2014: 1969-1972. (2014) https://pubmed.ncbi.nlm.nih.gov/25570367/
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