AH-INT-203

Associations of Urinary and Plasma Metabolites with Blood Pressure

High blood pressure is a major risk factor for heart disease and stroke, yet the biological mechanisms underlying its development are not fully understood. Metabolites — small molecules found in blood and urine — provide important clues about how the body processes nutrients and responds to disease. While several studies have explored the relationship between metabolites and blood pressure in blood samples, much less is known about the role of urine metabolites, and even fewer studies have compared findings between the two. This research aims to evaluate how plasma and urine metabolites are each associated with blood pressure and to assess where these associations overlap (concordance) or differ (discordance). 

By integrating information from both biological fluids, this study will offer a more comprehensive understanding of the metabolic pathways linked to blood pressure regulation and may help identify new biomarkers for prevention and treatment.

1. To evaluate the association between plasma metabolites and blood pressure.
2. To evaluate the association between urine metabolites and blood pressure.
3. To assess the concordance and discordance of the associations between plasma and urine metabolites with blood pressure.